Morpholine → HCID 19883113, compound

HRID 846586Notes

Reaction equation

HRID 846586 reaction equation
[F:1][C:2]1[N:7]=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:5]=[CH:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>C(Cl)(Cl)Cl>[N:12]1([S:8]([C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([F:1])[N:7]=2)(=[O:10])=[O:9])[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 157295366-Fluoropyridine-2-sulfonyl chloride

Product 1

HCID 19883113HCID 19883113, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To a solution of 6-fluoropyridine-2-sulphonyl chloride (1.96 g) in chloroform (40 cm3) at 0° C. was added a solution of morpholine (1.74 g) in chloroform (20 cm3). The reaction was quenched in water (100 cm3) and the product extracted into chloroform (3×50 cm3). The combined organic layers were washed with water, dried over anhydrous magnesium sulphate and the solvent evaporated under reduced pressure to give the title compound which was used without further purification.

Workup

  1. customThe reaction was quenched in water (100 cm3)
  2. extractionthe product extracted into chloroform (3×50 cm3)
  3. washThe combined organic layers were washed with water
  4. dry with materialdried over anhydrous magnesium sulphate
  5. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-ef7be755cc6f4a20b3d82e71de298a66
Source dataset
uspto-grants-1992_08
Patent number
US05137886

Reaction notes

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