Phosphorus sulfide (P2S5) → HCID 19883423, compound

HRID 846610Notes

Reaction equation

HRID 846610 reaction equation
[NH2:1][C:2]1[C:20]([Cl:21])=[CH:19][C:5]([C:6]([NH:8][CH2:9][C:10]2([OH:18])[CH:15]3[CH2:16][CH2:17][N:12]([CH2:13][CH2:14]3)[CH2:11]2)=O)=[C:4]([O:22][CH3:23])[CH:3]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:25].[S-2].[K+].[K+]>>[NH2:1][C:2]1[C:20]([Cl:21])=[CH:19][C:5]([C:6]([NH:8][CH2:9][C:10]2([OH:18])[CH:15]3[CH2:16][CH2:17][N:12]([CH2:13][CH2:14]3)[CH2:11]2)=[S:25])=[C:4]([O:22][CH3:23])[CH:3]=1

Participants

4

Reactant 3

HCID 14817Phosphorus sulfide (P2S5)HCID 162263Potassium SulfideHCID 9862752HCID 9862752, compound

Product 1

HCID 19883423HCID 19883423, compound

Procedure

4-Amino-5-chloro-N-(3-hydroxy-1-azabicyclo[2.2.2]octan-3-ylmethyl)2-methoxybenzamide is reacted with phosphorus pentasulfide and potassium sulfide using methods known to those skilled in the art to obtain the title compound.

Sources & evidence

ORD record
ord-f2af977216dd4274b3b82c5661f6bd62
Source dataset
uspto-grants-1992_08
Patent number
US05137895

Reaction notes

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