3-(Aminomethyl)quinuclidin-3-ol → HCID 19883416, compound

HRID 846612Notes

Reaction equation

HRID 846612 reaction equation
[OH:1][C:2]1([CH2:10][NH2:11])[CH:7]2[CH2:8][CH2:9][N:4]([CH2:5][CH2:6]2)[CH2:3]1.[NH2:12][C:13]1[C:21]([Cl:22])=[CH:20][C:16]([C:17](N)=[O:18])=[C:15]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([I:31])[CH:26]=2)[CH:14]=1>>[NH2:12][C:13]1[C:21]([Cl:22])=[CH:20][C:16]([C:17]([NH:11][CH2:10][C:2]2([OH:1])[CH:7]3[CH2:8][CH2:9][N:4]([CH2:5][CH2:6]3)[CH2:3]2)=[O:18])=[C:15]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([I:31])[CH:26]=2)[CH:14]=1

Participants

3

Reactant 2

HCID 147899783-(Aminomethyl)quinuclidin-3-olHCID 19883402HCID 19883402, compound

Product 1

HCID 19883416HCID 19883416, compound

Procedure

Following the procedure of Example 2, the title compound is prepared from 3-hydroxy-1-azabicyclo[2.2.2]oct-3-ylmethanamine and 4-amino-5-chloro-2-[(3-iodophenyl)methoxy]benzamide.

Sources & evidence

ORD record
ord-3cf0ece032db439aba6b17d5cf71ddd3
Source dataset
uspto-grants-1992_08
Patent number
US05137895

Reaction notes

Loading…