反应详情

20.6 g (83 mmol) of 1-(3,5-di-tert.-butyl-4-hydroxy-phenyl)ethanone were dissolved in 50 ml of methylene chloride with stirring and heated to boiling, and 14.4 g (90 mmol) of bromine were added dropwise in the course of 15 minutes. The mixture was then heated under reflux for a further 2 hours and cooled, 50 ml of water were added, and the organic phase was separated and dried over sodium sulfate. After removing the solvent under reduced pressure, the solid residue was recrystallized from methylcyclohexane.

1. temperatureheated
2. temperatureThe mixture was then heated
3. temperatureunder reflux for a further 2 hours
4. temperaturecooled
5. customthe organic phase was separated
6. dry with materialdried over sodium sulfate
7. customAfter removing the solvent under reduced pressure
8. customthe solid residue was recrystallized from methylcyclohexane