Acetone → HCID 205888, compound

Participants

Reaction Steps

5 Grams of cinnamyl bromide, 5 g of anhydrous piperazine and 50 ml of acetone solution containing 8.4 g of anhydrous potassium carbonate were refluxed for 6 hours. To the reaction mixture was added water and the whole mixture was extracted with chloroform. The chloroform layer was washed with water, dried and the solvent was removed by evaporation. 2.2 Grams of 1-acetyl-4-cinnamylpiperazine thus obtained was dissolved in 80% of methanol, and 2 g of potassium hydroxide was added thereto, then the mixture was refluxed for 8 hours. To the reaction mixture was added water, and the whole mixture was extracted with chloroform, washed with water, dried, and chloroform was removed by evaporation. The residue thus obtained was purified by means of a silica gel column chromatography (eluent: chloroform and chloroform:methanol=30:1) to yield 1.2 g of N-cinnamylpiperazine.

Provenance & Evidence