Methyl acetoacetate → Methyl 4-bromo-3-oxobutanoate

To 150 ml of anhydrous carbon tetrachloride solution containing 116 g of methyl acetoacetate was added dropwise 51 ml of bromine at below 5° C. After the addition was finished the reaction mixture was stirred overnight, then the reaction mixture was poured into ice-water, washed with a diluted sodium carbonate aqueous solution five times, then with a saturated sodium chloride aqueous solution, and dried with anhydrous calcium chloride. The solvent was removed by evaporation to yield 170 g of methyl 4-bromoacetoacetate.

1. additionAfter the addition
2. washwashed with a diluted sodium carbonate aqueous solution five times
3. dry with materialwith a saturated sodium chloride aqueous solution, and dried with anhydrous calcium chloride
4. customThe solvent was removed by evaporation

ORD record

ord-e26b683022364437a7ef1ee93cf14407

Source dataset

uspto-grants-1992_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05137889