p-Tolyl isothiocyanate → 3-(4-Methylphenyl)-5-[[(phenylmethyl)thio]methyl]-2-thioxo-4-imidazolidinone

Participants

Reaction Steps

When 10 g of S-benzylcysteine (0.0473 mole), 1.89 g of sodium hydroxide (0.0473 mole) and 7.05 g of p-tolylisothiocyanate (0.0473 mole) was reacted according to the procedure outlined in the preparation of Example 2, 18.1 g of the crude thiourea was obtained and 14.3 g of pure title compound was obtained: RF on silica gel=approximately 0.33 [ethyl acetate-hexane (3:7)].

Provenance & Evidence