HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrafluoro-m-phenylenediamine dihydrochloride → (S)-1-[3-(2-pyrrolidinyl)-2-propynyl]pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | (R)-t-butyl 2-[3-(1-pyrrolidinyl)-1-propynyl]-1-pyrrolidinecarboxylate | HCID 9860463 | — |
| Reactant | 1-Pyrrolidinecarboxylate | HCID 22325173 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-1-[3-(2-pyrrolidinyl)-2-propynyl]pyrrolidine | HCID 14730290 | 26% |
Reaction Steps
This compound was obtained as the dihydrochloride salt following Example 50, Part A by substituting (S)-t-butyl (1-pyrrolidinyl)-1-propynyl]-1-pyrrolidinecarboxylate for (R)-t-butyl 2-[3-(1-pyrrolidinyl)-1-propynyl]-1-pyrrolidinecarboxylate, a white hygroscopic powder, m.p. 208°-211° C. [a]D -23° (c 0.75, MeOH). Recrystallization of the mother liquor gave an additional 26% of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05137905 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-5e162bc6e4b849dc90cb0670aef86f49 |
| Source note | uspto-grants-1992_08 |