Ethyl bromoacetate → Ethyl 2-(1-ethoxycarbonylmethylindol-2-yl)thio-2-phenylpropionate

HRID 846678Notes

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[S:10][C:11]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13].Br[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27]>>[CH2:29]([O:28][C:26]([CH2:25][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[S:10][C:11]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[O:27])[CH3:30]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 15724966Ethyl 2-(1H-indol-2-yl)thio-2-phenylpropionate

Product 1

HCID 15725029Ethyl 2-(1-ethoxycarbonylmethylindol-2-yl)thio-2-phenylpropionateYield 63%

Procedure

Starting from ethyl 2-(1H-indol-2-yl)thio-2-phenylpropionate and ethyl bromoacetate, the title compound was obtained as a pale yellow oily matter (yield: 63 %) according to the method of Example 92.

Sources & evidence

ORD record: ord-68c1ee61539c4dce8219b79a88136e67
Source dataset: uspto-grants-1992_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05137909

Reaction notes

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