反应详情

To a solution of 29,3 g of 2-chloroethanol in toluene 2 ml of concentrated sulphuric acid were added, after which 50 g of 4,4'-difluorobenzhydrol were added under stirring. The mixture was refluxed for 2 h, cooled and more toluene added. The organic phase was washed successively with water, aqueous sodium carbonate, and water and then dried. The solvent was evaporated to give 65 g of a crude product which was distilled to obtain 57.5 g (89,5%) of [1-(2-chloroethyl)]-bis-(4-fluorophenyl)methane.

1. temperatureThe mixture was refluxed for 2 h
2. temperaturecooled
3. washThe organic phase was washed successively with water, aqueous sodium carbonate, and water
4. customdried
5. customThe solvent was evaporated
6. customto give 65 g of a crude product which
7. distillationwas distilled