反应详情

Following procedures similar to Step 5 of Example 1, a 0.186 g (1.4 mmol) sample of 3,3-dimethoxypyrrolidine, from Step 4 of Example 1, was reacted with 0.200 g (0.7 mmol) of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (preparation described by K. Grohe, et al., DE 3142854, May, 1983) at 60° C. under N2 for 188 hours to yield the title compound, mp 224°-226° C.: MS (DCl) M/Z 377 (M+H); NMR d 1.42 (d, 1H), 1.63 (m, 2H), 3.75 (s, 3H), 3.99 (s, 3H), 4.02 (m, 1H), 4.26 (m, 2H), 4.40 (m, 2H), 7.46 (d, 1H, J=7.5 Hz), 8.13 (d, 1H, J=13.5 Hz), 9.19 (s, 1H). Analysis calculated for C19H21FN2O5 ·0.5 H2O: C, 59.21; H, 5.75; N, 7.27. Found: C, 59.70; H, 5.48; N, 7.13.