Hydrochloric Acid → HCID 67917375, compound

Participants

Reaction Steps

The 0.394 g of the ester from Step 2 was hydrolyzed by the procedure of Step 2 Example 387. The residue was poured into water and conc. HCl was added to adjust the acidity to pH 1. The product was filtered off, stirred in 1:1 methanol/methylene chloride for 2 hours, filtered, and the filtrate dried to afford 0.252 g of the title compound, mp 179°-181° C.; MS (DCl) M/Z 405 (M+H). NMR (TFA/AA) d 1.40 (m, 4H), 4.10 (m, 12H), 8.08 (d, 1H, J=12 Hz), 9.12 (s, 1H). Analysis calculated for C19H22ClFN4O5 ·H2O: C, 47.85; H, 5.50; N, 11.75. Found: C, 48.54; H, 5.12; N, 11.23.

Provenance & Evidence