HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → a-(3-Bromopropyl)-4-fluoro-alpha-(4-fluorophenyl)benzeneacetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 14230261 | HCID 14230261 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | a-(3-Bromopropyl)-4-fluoro-alpha-(4-fluorophenyl)benzeneacetyl chloride | HCID 19883439 | — |
Reaction Steps
To a stirred solution of 29.5 parts of α-(3-bromopropyl)-4-fluoro-α-(4-fluorophenyl)benzeneacetic acid in 300 parts of trichloromethane were added 28.8 parts of thionyl chloride and the whole was stirred and refluxed for 3 hours. The reaction mixture was evaporated, yielding 30 parts of α-(3-bromopropyl)-4-fluoro-α-(4-fluorophenyl)-benzeneacetyl chloride as a residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05137896 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-dcfad30f419a4776becb5db6389dba36 |
| Source note | uspto-grants-1992_08 |