HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 14054009, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-Nitroaniline | HCID 6946 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | HCID 54356780 | HCID 54356780 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 14054009 | HCID 14054009 | — |
Reaction Steps
N-(2'-Nitrophenyl)-4-(3-benzyloxypropanoylamino)-benzamide is prepared analogously to Example 1 using 12 g (40.1 mMole) 4 (3 benzyloxypropanoylamino)-benzoic acid, 6.6 g (0.13 mMole) oxalyl chloride, 9.7 g (0.13 mole) dimethylformamide, 2×4.5 g pyridine, 6.1 g (44.1 mMole) o-nitroaniline, and 280 mL dry ethyl acetate. The crude product is purified by column chromatography (silica gel; ethyl acetate/n hexane 1:5-1:1 v/v). Yield 3.5 g (21% of theory); m.p. 140° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05137918 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-69aa677fe66f4e5d8f1769857a78de70 |
| Source note | uspto-grants-1992_08 |