HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 14054010, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-Nitroaniline | HCID 6946 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-(2-Methylpropanamido)benzoic acid | HCID 506050 | — |
| Reactant | HCID 86746071 | HCID 86746071 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 14054010 | HCID 14054010 | — |
Reaction Steps
N-(2'-Nitrophenyl)-4-isobutyrylaminobenzamide is prepared under the reaction conditions given in Example 5: after the addition of pyridine/o-nitroaniline, the reaction solution is stirred for 15 hours at ambient temperature and for 5 hours at boiling temperature, the following components being used: 54.6 g (74.68 mMole) dimethylformamide, 1.5 L dry ethyl acetate, 37.3 g (29.42 mMole) oxalyl chloride, 47 g (22.63 mMole) 4-isobutyrylaminobenzoic acid, 34.4 g (24.89 mMole) o-nitroaniline, and 25.6 g (32.36 mMole) pyridine. The product is recrystallized from ethyl acetate. Yield 13.3 g (18% of theory); m.p. 237.6° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05137918 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-075bae4af1d44d54a226c5ba3f700344 |
| Source note | uspto-grants-1992_08 |