Water → HCID 18452829, compound

Participants

Reaction Steps

35.7 g (0.26 mole) p-aminobenzoic acid, together with 23.7 g (0.30 mole) pyridine, are dissolved in 420 mL dioxan and mixed dropwise at 15° C. with 51.7 g (0.28 mole) benzyloxyacetic acid chloride (Heterocyclic Chem., 15, 601, 1978). After stirring for 2 hours at ambient temperature, the reaction mixture is mixed with 300 mL water. The precipitate obtained is filtered off with suction, washed with water, and dried. The product is used for the next step without further purification. Yield 63 g (98.3% of theory); m.p. 178°-179° C.

Provenance & Evidence