Iodoethane → HCID 19883210, compound

Participants

Reaction Steps

A suspension of sodium hydride (12.7 g, 320 mmol), washed three times pentanes, in dimethylformamide (200 mL) was treated with 2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine dihydrochloride (35.3 g, 110 mmol). The mixture was stirred at room temperature for 2 hours, and iodoethane (8.8 mL, 110 mmol) was added. The mixture was stirred at room temperature overnight, quenched with water and the resulting precipitate was collected by filtration to give 31.5 g (79%) of 2-amino-4-(4-chlorophenyl)-6-ethyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine dihydrochloride. m.p.>260° C. MS: 289 (MH+). IR(KBr): 3224, 2641, 2311, 1623 cm-1.

Provenance & Evidence