Allyl bromide → HCID 19883237, compound

HRID 846824Notes

Reaction equation

HRID 846824 reaction equation
[ClH:1].Cl.[NH2:3][C:4]1[N:5]=[C:6]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[C:7]2[CH2:13][NH:12][CH2:11][CH2:10][C:8]=2[N:9]=1.[CH2:21](Br)[CH:22]=[CH2:23]>>[ClH:20].[ClH:1].[CH2:23]([N:12]1[CH2:11][CH2:10][C:8]2[N:9]=[C:4]([NH2:3])[N:5]=[C:6]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[C:7]=2[CH2:13]1)[CH:22]=[CH2:21]

Participants

3

Reactant 2

HCID 7841Allyl bromideHCID 19883214HCID 19883214, compound

Product 1

HCID 19883237HCID 19883237, compoundYield 77.3%

Procedure

The title compound was prepared as described in Example 17 starting with 2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine dihydrochloride (1.5 g, 4.5 mmol) and allyl bromide (0.4 mL, 4.6 mmol) instead of iodoethane to produce 0.65 g (39%) of 6-allyl-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine dihydrochloride. m.p. 248°-250° C. MS: 301 (MH+).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-b4857d121af54627aca9d11f8206d6bb
Source dataset
uspto-grants-1992_08
Patent number
US05137890

Reaction notes

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