Allyl bromide → HCID 19883224, compound

HRID 846825Notes

Reaction equation

O.[ClH:2].Cl.[NH2:4][C:5]1[N:6]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[C:8]2[CH2:14][NH:13][CH2:12][CH2:11][C:9]=2[N:10]=1.NC1N=[C:25]([C:33]2C=CC(F)=CC=2)[C:26]2CNCCC=2N=1.Cl.Cl.C(Br)C=C>>[ClH:2].[ClH:2].[CH2:33]([N:13]1[CH2:12][CH2:11][C:9]2[N:10]=[C:5]([NH2:4])[N:6]=[C:7]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[C:8]=2[CH2:14]1)[CH:25]=[CH2:26]

Participants

Reactant 2

HCID 7841Allyl bromide

HCID 131717489HCID 131717489, compound

Product 1

HCID 19883224HCID 19883224, compoundYield 117.4%

Procedure

The title compound was prepared as described in Example 17 starting with 2-amino-4-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine dihydrochloride hemihydrate (1.0 g, 3.1 mmol) and allyl bromide (0.3 mL, 3.1 mmol) instead of iodoethane to produce 0.65 g (59%) of 6-allyl-2-amino-4-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine dihydrochloride. m.p. 241°-243° C. MS: 285 (MH+). IR(KBr): 3305, 3118, 2476, 1651 cm-1.

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-97148c3ad53c4839ae893acabc05ba9a
Source dataset: uspto-grants-1992_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05137890

Reaction notes

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