3-(Dimethylamino)propyl chloride hydrochloride → HCID 19883242, compound

HRID 846827Notes

Reaction equation

HRID 846827 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:5]2[CH2:11][NH:10][CH2:9][CH2:8][C:6]=2[N:7]=1.[ClH:19].[CH3:20][N:21]([CH2:23][CH2:24][CH2:25][Cl:26])[CH3:22]>>[ClH:26].[ClH:19].[ClH:26].[NH2:1][C:2]1[N:3]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:5]2[CH:11]([CH2:25][CH2:24][CH2:23][N:21]([CH3:22])[CH3:20])[NH:10][CH2:9][CH2:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 943083-(Dimethylamino)propyl chloride hydrochlorideHCID 10105870HCID 10105870, compound

Product 1

HCID 19883242HCID 19883242, compoundYield 34%

Procedure

The title compound was prepared as described in Example 17 starting with 2-amino-4-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (2.0 g, 8.2 mmol) and dimethylaminopropylchloride hydrochloride (2.6 g, 16.4 mmol) to give 0.91 g (34%) of 2-amino-4-(4- fluorophenyl)-5,6,7,8-tetrahydro-5-(3-dimethylaminopropyl)pyrido[4,3-d]pyrimidine trihydrochloride. m.p. 241°-243° C. MS: 329(MH+).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-c47e34218d2d4166ab8d3f12ae6c7995
Source dataset
uspto-grants-1992_08
Patent number
US05137890

Reaction notes

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