HRID846905

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID19022435

未命名化合物

结构：Cc1cc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)C(=O)c4csc(N)n4)[C@H]3SC2)nc2c(C(=O)O)cnn12

HCID86744946

未命名化合物

PRODUCTS

生成物

$结构：Cc1cc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)/C(=N\OCS(=O)(=O)c4ccc(O)c(O)c4)c4csc(N)n4)[C@H]3SC2)nc2c(C(=O)O)cnn12$

HCID88442879

未命名化合物

PROCEDURE

实验过程

307 mg of 4-[[(aminooxy)methyl]sulphonyl]pyrocatechol were reacted with 575 mg of (6R,7R)-7-(2-amino-4-thiazoleglyoxylamido)-3-[[(3-carboxy-7-methylpyrazolo[1,5-a]pyrimidin-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid in an analogous manner to the procedure described in Examples 11 or 7. There was obtained (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-[[[(3,4-dihydroxyphenyl)sulphonyl]methoxy]imino]acetamido]-3-[[(3-carboxy-7-methylpyrazolo[1,5-a]pyrimidin-5-yl)thio]-methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid as a white powder.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f241a6b763ea437d8acb1183d04342b2
来源数据集: uspto-grants-1992_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05138066
来源说明: uspto-grants-1992_08

反应 SMILES

[NH2:1][O:2][CH2:3][S:4]([C:7]1[CH:8]=[C:9]([OH:14])[C:10](=[CH:12][CH:13]=1)[OH:11])(=[O:6])=[O:5].[NH2:15][C:16]1[S:17][CH:18]=[C:19]([C:21](=O)[C:22]([NH:24][C@@H:25]2[C:32](=[O:33])[N:31]3[C@@H:26]2[S:27][CH2:28][C:29]([CH2:37][S:38][C:39]2[CH:44]=[C:43]([CH3:45])[N:42]4[N:46]=[CH:47][C:48]([C:49]([OH:51])=[O:50])=[C:41]4[N:40]=2)=[C:30]3[C:34]([OH:36])=[O:35])=[O:23])[N:20]=1>>[NH2:15][C:16]1[S:17][CH:18]=[C:19](/[C:21](=[N:1]/[O:2][CH2:3][S:4]([C:7]2[CH:13]=[CH:12][C:10]([OH:11])=[C:9]([OH:14])[CH:8]=2)(=[O:5])=[O:6])/[C:22]([NH:24][C@@H:25]2[C:32](=[O:33])[N:31]3[C@@H:26]2[S:27][CH2:28][C:29]([CH2:37][S:38][C:39]2[CH:44]=[C:43]([CH3:45])[N:42]4[N:46]=[CH:47][C:48]([C:49]([OH:51])=[O:50])=[C:41]4[N:40]=2)=[C:30]3[C:34]([OH:36])=[O:35])=[O:23])[N:20]=1