1-Acetylpiperazine → 8-(4-acetylpiperazin-1-yl)-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-Acetylpiperazine	HCID 83795	—
Reactant	8-bromo-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide	HCID 57900337	—
Product	8-(4-acetylpiperazin-1-yl)-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide	HCID 44241962	—

Reaction Steps

Following Example 70 and General Procedure D, 8-bromo-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide 160bp and 1-acetylpiperazine were reacted to give 120bp. 1H NMR (400 MHz, CDCl3) δ 7.23 (m, 1 H), 6.82-6.93 (m, 5 H), 5.99 (s, 1 H), 5.01 (s, 2 H), 3.86 (m, 2 H), 3.73 (m, 2 H), 3.32 (s, 3 H), 3.21 (m, 2 H), 3.16 (m, 2 H), 2.13 (s, 3 H). LCMS (ESI) m/z: 484.1

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846762B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-a5ac1a7302b34e7b9f2931872ce03c22
Source note	uspto-grants-2014_09