2-tert-Butoxycarbonylamino-3-octadecylcarbamoyloxypropylamine → 2-Tert-butoxycarbonylamino-3-(3-chloropropylsulfonylamino)-1-hexadecylthiopropane

HRID 846987Notes

Reaction equation

HRID 846987 reaction equation
[C:1]([O:5][C:6]([NH:8]C(COC(=O)NCCCCCCCCCCCCCCCCCC)CN)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:35][CH2:36][CH2:37][CH2:38][S:39]([NH:42][CH2:43][CH:44](OC)[CH2:45][S:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH3:62])(=[O:41])=[O:40]>>[C:1]([O:5][C:6]([NH:8][CH:44]([CH2:43][NH:42][S:39]([CH2:38][CH2:37][CH2:36][Cl:35])(=[O:40])=[O:41])[CH2:45][S:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH3:62])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 148350012-tert-Butoxycarbonylamino-3-octadecylcarbamoyloxypropylamineHCID 14835022HCID 14835022, compound

Product 1

HCID 148350422-Tert-butoxycarbonylamino-3-(3-chloropropylsulfonylamino)-1-hexadecylthiopropane

Procedure

3-Hexadecylthio-2-tert-butoxycarbonylaminopropylamine IV e4 is allowed to react and worked up by the same procedure as described in (4). m.p. 100.5°-101.5° C. The summary of the experimental condition and the physical data of the product are listed in Table 7.

Workup

  1. customto react

Sources & evidence

ORD record
ord-3be742f95f12401e9a7b1b8f5b216bb5
Source dataset
uspto-grants-1992_08
Patent number
US05138067

Reaction notes

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