4-Morpholinopiperidine → N-(2,4-difluorophenyl)-N-methyl-8-(4-morpholinopiperidine-1-yl)-4H-thieno[3,2-c]chromene-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	4-Morpholinopiperidine	HCID 795724	—
Reactant	8-bromo-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide	HCID 57900337	—
Product	N-(2,4-difluorophenyl)-N-methyl-8-(4-morpholinopiperidine-1-yl)-4H-thieno[3,2-c]chromene-2-carboxamide	HCID 44241964	—

Reaction Steps

Following Example 70 and General Procedure D, 8-bromo-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide 160bp and 4-(4-piperidinyl)morpholine were reacted to give 127bp. 1H NMR (400 MHz, CDCl3) δ 7.20 (m, 1 H), 7.05-7.10 (m, 2 H), 6.84-6.93 (m, 3 H), 6.74 (m, 1 H), 5.05 (s, 2 H), 4.00 (m, 4 H,), 3.63-3.68 (m, 3 H), 3.29-3.50 (m, 5 H), 3.18 (m, 2 H), 3.05 (m, 2H), 2.47 (m, 2 H), 2.21 (m, 2 H). LCMS (ESI) m/z: 526.1

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846762B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-bb2a321cd09c4480bf826ee86c79f5cf
Source note	uspto-grants-2014_09