HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 847013Generated: October 30, 2026
Ethyl Acetate → 2-Cyanomethyl-3-hexadecyloxypropyl benzoate
https://huagongshe.com/reaction/847013
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 2-Bromomethyl-3-hexadecyloxypropanol benzoate | HCID 53797848 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Cyanomethyl-3-hexadecyloxypropyl benzoate | HCID 54541187 | 100.6% |
Reaction Steps
A mixture of 13.845 g (27.9 mM) of 2-bromomethyl-3-n-hexadecyloxypropyl benzoate n3 and 1.439 g (27.9 mM) of sodium cyanide (95% purity) in 150 ml of dimethylsulfoxide is heated at 90° C. for 1 hour. The product is isolated by ethyl acetate extraction. The ethyl acetate layer is washed with water (four times) and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and evaporated to obtain 12.42 g of the crude product of the titled compound n3'.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05138067 |
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| Source dataset | uspto-grants-1992_08 |
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| ORD ID | ord-bb0dbdf8d9b4421a8c09d5ab7bc707d4 |
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| Source note | uspto-grants-1992_08 |
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