HRID847016

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8929

Sodium cyanide (Na(CN))

CNNa

结构：CCCCCCCCCCCCCCCCCCNC(=O)OCC(CBr)COC(=O)c1ccccc1

HCID53884469

未命名化合物

结构：CCCCCCCCCCCCCCCCOCC(CC#N)COC(=O)c1ccccc1

HCID54541187

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCCCNC(=O)OCC(CC#N)COC(=O)c1ccccc1

HCID54117556

未命名化合物

收率 95.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

A mixture of 1.76 g (3.10 mM) of 2-bromomethyl-3-n-octadecylcarbamoyloxypropyl benzoate, 185 mg (3.26 mM) of 95% sodium cyanide in 30 ml of dimethylsulfoxide is allowed to react by the same procedure as described in the (136) and 1.49 g (95.5% yield) of the titled compound n5' is obtained.

WORKUP

后处理

customto react by the same procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f9866956e8c648038bdf9bdc1f23aa8e
来源数据集: uspto-grants-1992_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05138067
来源说明: uspto-grants-1992_08

反应 SMILES

[C:1]([O:9][CH2:10][CH:11]([CH2:35]Br)[CH2:12][O:13][C:14](=[O:34])[NH:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C-]#N.[Na+].C(OCC(C[C:70]#[N:71])COCCCCCCCCCCCCCCCC)(=O)C1C=CC=CC=1>CS(C)=O>[C:1]([O:9][CH2:10][CH:11]([CH2:35][C:70]#[N:71])[CH2:12][O:13][C:14](=[O:34])[NH:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1