HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → Ethyl 2-(4,6-dimethylpyrimidin-2-yl)oxyacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 4,6-Dimethylpyrimidin-2-ol | HCID 9508 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-(4,6-dimethylpyrimidin-2-yl)oxyacetate | HCID 3410252 | 26.8% |
Reaction Steps
2-Hydroxy-4,6-dimethyl pyrimidine (10g, 0.08 mol) was dissolved in 150ml of dimethylformamide. Ethyl bromoacetate (13.5g, 0.08 mol) was added and also, subsequently, 11.lg of potassium carbonate. The reaction mixture was refluxed overnight. A precipitate had formed which was filtered off and the solvent was then evaporated off from the filtrate to form a crude oily product. Following purification by flash chromatography, 4.5g of the title product were obtained in the form of a red oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05139563 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-83d2bb0b404543c793d87e333bd2852c |
| Source note | uspto-grants-1992_08 |