HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 2-(4,6-dimethoxypyrimidin-2-yl)oxybut-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-hydroxybut-3-enoate | HCID 545123 | — |
| Reactant | 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine | HCID 838363 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | Methyl 2-(4,6-dimethoxypyrimidin-2-yl)oxybut-2-enoate | HCID 53952661 | 78.1% |
Reaction Steps
A mixture of methyl 2-hydroxybut-3-enoate (0.80g, 6.9mmol), 4,6-dimethoxy-2-methanesulphonylpyrimidine (1.50g, 6.9mmol) and potassium carbonate (1.04g, 7.6mmol) in methyl ethyl ketone (100ml) was refluxed for 12 hours. The reaction mixture was filtered and the filtrate evaporated in vacuo. Flash column chromatography (silica, 1.5% methanol in chloroform) of the residue gave the title compound (1.37g, 78% yield by weight).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05139563 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-926200faf6b44bfaa25326ff0c79f915 |
| Source note | uspto-grants-1992_08 |