Sodium Hydroxide → HCID 13218156, compound

Participants

Reaction Steps

A diester, trans-1,2-di-carbomethoxy-4-methylenecyclopentane, 1 (1.48g, 7.47 mmol) prepared by the method of Trost (J. Am. Chem. Soc. 105 2315 (1983) was heated under reflux for 2 hours with 2N sodium hydroxide (11 ml, 22 mmol). The resulting solution was cooled in an ice bath and acidified with concentrated (37%) hydrochloric acid (8.0 ml) until a pH of 0.6 was attained. .The resulting slurry was filtered, washed with water, and dried in vacuo to give the diacid 2 (0.987g, 77.7%) as a colorless powder: mp 178°-179° C.; Anal. calcd for C8H10O4 : C, 56.47; H, 5.92. Found: C, 56.08; H, 5.87.

Provenance & Evidence