HCID 19100862, compound → HCID 54037348, compound

HRID 847157Notes

Reaction equation

HRID 847157 reaction equation
CN(C)C1NC(=O)[C:6](CCO)=[C:5]([CH3:13])N=1.[Cl:15][CH2:16][CH2:17][C:18]1[C:19](=[O:29])[N:20]([CH3:28])[C:21]([N:25]([CH3:27])C)=[N:22][C:23]=1[CH3:24].ClCCC1C(=O)N(CCC)C(N(C)C)=NC=1C.Cl.ClCCC1C(=O)N(CC)C(N(C)C)=NC=1C>>[CH2:27]([NH:25][C:21]1[N:20]([CH3:28])[C:19](=[O:29])[C:18]([CH2:17][CH2:16][Cl:15])=[C:23]([CH3:24])[N:22]=1)[CH2:6][CH2:5][CH3:13]

Participants

5

Reactant 4

HCID 19100862HCID 19100862, compoundHCID 19100924HCID 19100924, compoundHCID 19100930HCID 19100930, compoundHCID 135736976HCID 135736976, compound

Product 1

HCID 54037348HCID 54037348, compound

Procedure

and further, following the same procedures 2-dimethylamino-5-(2-hydroxyethyl)-6-methyl-4(3H)-pyrimidinone (Coll. Czech. Chem. Commun., 32, 1582, 1967) was converted into 5-(2-chloroethyl)-2-(dimethylamino)-3,6-dimethyl-4(3H)-pyrimidinone (interm. 32); 5-(2-chloroethyl)-2-(dimethylamino)-6-methyl-3-propyl-4(3H)-pyrimidinone (interm. 33); and 5-(2-chloroethyl)-2-(dimethylamino)-3-ethyl-6-methyl-4(3H)-pyrimidinone monohydrochloride (interm. 34).

Sources & evidence

ORD record
ord-bdc2a27e9a144771b820be49f0eac99f
Source dataset
uspto-grants-1992_08
Patent number
US05140029

Reaction notes

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