1-Chloro-2-isothiocyanatobenzene → N-(2-chlorophenyl)-N'-cyanothiourea

HRID 847176ノート

反応式

HRID 847176 の反応式
[N:1]#[C:2][NH2:3].[Na].[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]=[C:13]=[S:14]>C(O)C>[C:2]([NH:3][C:13]([NH:12][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[Cl:5])=[S:14])#[N:1]

参加物

4

反応物 2

HCID 1231711-Chloro-2-isothiocyanatobenzeneHCID 57375518Cyanamidnatrium

生成物 1

HCID 11769784N-(2-chlorophenyl)-N'-cyanothiourea収率 96.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The suspension of monosodium cyanamide (1.9 g, 29.4 mmol) in absolute ethanol (50 mL) was slowly treated with 2-chlorophenylisothiocyanate (5.0 g, 29.4 mmol). The reaction was allowed to stir at room temperature for 1 hour and then heated at 75° C. for 4 hours. The reaction was cooled to room temperature and the colorless solid was filtered and washed with ethanol to give the title A compound (6.0 g), m.p. 253°-255° C.

後処理

  1. temperatureheated at 75° C. for 4 hours
  2. temperatureThe reaction was cooled to room temperature
  3. filtrationthe colorless solid was filtered
  4. washwashed with ethanol

出典と根拠

ORDレコード
ord-4ed00b5e462c488db6a4cc5e226ede5f
出典データセット
uspto-grants-1992_08
特許番号
US05140031

反応ノート

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