3-Chlorophenyl isothiocyanate → HCID 12050727, compound

HRID 847177Notes

Reaction equation

HRID 847177 reaction equation
[N:1]#[C:2][NH2:3].[Na].[Cl:5][C:6]1[CH:7]=[C:8]([N:12]=[C:13]=[S:14])[CH:9]=[CH:10][CH:11]=1>C(O)C>[C:2]([NH:3][C:13]([NH:12][C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([Cl:5])[CH:7]=1)=[S:14])#[N:1]

Participants

4

Reactant 2

HCID 754493-Chlorophenyl isothiocyanateHCID 57375518Cyanamidnatrium

Product 1

HCID 12050727HCID 12050727, compoundYield 86.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The suspension of monosodium cyanamide (1.9 g, 29.4 mmol) in absolute ethanol (50 mL) was slowly treated with 3-chlorophenylisothiocyanate (5.0 g, 29.4 mmol). The reaction was allowed to stir at room temperature for 1 hour and then heated at 75° C. for 4 hours. The reaction was cooled to room temperature and the colorless solid was filtered and washed with ethanol to give the title A compound (5.4 g), m.p. 258°-260° C.

Workup

  1. temperatureheated at 75° C. for 4 hours
  2. temperatureThe reaction was cooled to room temperature
  3. filtrationthe colorless solid was filtered
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-9c7a431afe61481080f65e3c5db4afa0
Source dataset
uspto-grants-1992_08
Patent number
US05140031

Reaction notes

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