4-Fluorophenyl isothiocyanate → HCID 19882402, compound

HRID 847178Notes

Reaction equation

HRID 847178 reaction equation
[N:1]#[C:2][NH2:3].[Na].[F:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]=[C:13]=[S:14])=[CH:8][CH:7]=1>C(O)C>[C:2]([NH:3][C:13]([NH:12][C:9]1[CH:10]=[CH:11][C:6]([F:5])=[CH:7][CH:8]=1)=[S:14])#[N:1]

Participants

4

Reactant 2

HCID 152414-Fluorophenyl isothiocyanateHCID 57375518Cyanamidnatrium

Product 1

HCID 19882402HCID 19882402, compoundYield 64.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The suspension of monosodium cyanamide (2.1 g, 32.6 mmol) in absolute ethanol (50 mL) was slowly treated with 4-fluorophenylisothiocyanate (5.0 g, 32.6 mmol). The reaction was allowed to stir at room temperature for 1 hour and then heated at 75° C. for 4 hours. The reaction was cooled to room temperature and the colorless solid was filtered and washed with ethanol to give the title A compound (4.1 g), m.p. >270° C.

Workup

  1. temperatureheated at 75° C. for 4 hours
  2. temperatureThe reaction was cooled to room temperature
  3. filtrationthe colorless solid was filtered
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-d4ff5564cfe34ec5ae9f29a733535db6
Source dataset
uspto-grants-1992_08
Patent number
US05140031

Reaction notes

Loading…