4-Nitrophenol → HCID 178521452, compound

Participants

Reaction Steps

To a solution of 2.0 g. (5.3 mMol) cis-4-[2-(4-chlorobenzenesulphonylamino)-ethyl]-cyclohexylacetic acid and 25 ml. anhydrous tetrahydrofuran is added drop-wise 0.86 g. (5.3 mMol) carbonyl-bis-imidazole. The reaction mixture is stirred for 10 minutes, 0.74 g. (5.3 mMol) 4-nitrophenol is added thereto, followed by further stirring for 10 minutes at 40° C. 0.91 g. (100 mMol) anhydrous 5-amino-1,2,3,4-tetrazole is then added thereto. The reaction mixture is kept at 60° C. for 3 hours, then evaporated in a vacuum and the residue is stirred with 0.5N hydrochloric acid. After filtering off with suction and washing with water, the product obtained is recrystallised from ethanol. Yield 1.40 g. (59% of theory); m.p. 191°-192° C.

Provenance & Evidence