Boc-L-phenylalanine methyl ester → Methyl 2-((tert-butoxycarbonyl)amino)-3-cyclohexylpropanoate

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Reaction Steps

315.3 g (1.28 mmol) of t-butoxycarbonyl-L-phenylalanine methyl ester are hydrogenated in the presence of 5% rhodium on aluminium oxide at room temperature and 440 kPa according to the method described by J. Boger et al. in J. Med. Chem., 28, 1779 (1985), whereby there are obtained 315.3 g of methyl 2-t-butoxycarbonylamino-3-cyclohexylpropionate as an oil which is used directly in the next step.

Provenance & Evidence