HRID847327

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCNC(=O)C[C@@H](C[C@H](O)[C@@H](N)CC1CCCCC1)C(C)C

HCID57081964

未命名化合物

结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O

HCID178454152

未命名化合物

PRODUCTS

生成物

结构：CCCCNC(=O)C[C@@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(C)C

HCID178449483

未命名化合物

PROCEDURE

实验过程

In an analogous manner to that described in Example 9, by reacting (3R,5S,6S)-6-amino-7-cyclohexyl-5-hydroxy-3-isopropylheptanoic acid butylamide with Boc-Phe-His-OH there is obtained t-butyl [(S)-α-[[(S)-1-[[(1S,2S,4R)-4-[(butylcarbamoyl)methyl]-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]phenethyl]carbamate as an amorphous solid, MS: 725 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e51bdf024b7144b184df54400f57c3d8
来源数据集: uspto-grants-1992_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05140011
来源说明: uspto-grants-1992_08

反应 SMILES

[CH2:1]([NH:5][C:6](=[O:24])[CH2:7][C@H:8]([CH:21]([CH3:23])[CH3:22])[CH2:9][C@H:10]([OH:20])[C@@H:11]([NH2:19])[CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[CH2:2][CH2:3][CH3:4].[NH:25]([C:47]([O:49][C:50]([CH3:53])([CH3:52])[CH3:51])=[O:48])[C@H:26]([C:34]([NH:36][C@H:37]([C:44](O)=[O:45])[CH2:38][C:39]1[N:43]=[CH:42][NH:41][CH:40]=1)=[O:35])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH2:1]([NH:5][C:6]([CH2:7][C@H:8]([CH:21]([CH3:23])[CH3:22])[CH2:9][C@H:10]([OH:20])[C@@H:11]([NH:19][C:44]([C@@H:37]([NH:36][C:34]([C@@H:26]([NH:25][C:47](=[O:48])[O:49][C:50]([CH3:52])([CH3:51])[CH3:53])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:35])[CH2:38][C:39]1[N:43]=[CH:42][NH:41][CH:40]=1)=[O:45])[CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)=[O:24])[CH2:2][CH2:3][CH3:4]