HCID 57081964, compound → HCID 178449483, compound

HRID 847327Notes

Reaction equation

HRID 847327 reaction equation
[CH2:1]([NH:5][C:6](=[O:24])[CH2:7][C@H:8]([CH:21]([CH3:23])[CH3:22])[CH2:9][C@H:10]([OH:20])[C@@H:11]([NH2:19])[CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[CH2:2][CH2:3][CH3:4].[NH:25]([C:47]([O:49][C:50]([CH3:53])([CH3:52])[CH3:51])=[O:48])[C@H:26]([C:34]([NH:36][C@H:37]([C:44](O)=[O:45])[CH2:38][C:39]1[N:43]=[CH:42][NH:41][CH:40]=1)=[O:35])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH2:1]([NH:5][C:6]([CH2:7][C@H:8]([CH:21]([CH3:23])[CH3:22])[CH2:9][C@H:10]([OH:20])[C@@H:11]([NH:19][C:44]([C@@H:37]([NH:36][C:34]([C@@H:26]([NH:25][C:47](=[O:48])[O:49][C:50]([CH3:52])([CH3:51])[CH3:53])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:35])[CH2:38][C:39]1[N:43]=[CH:42][NH:41][CH:40]=1)=[O:45])[CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)=[O:24])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 57081964HCID 57081964, compoundHCID 178454152HCID 178454152, compound

Product 1

HCID 178449483HCID 178449483, compound

Procedure

In an analogous manner to that described in Example 9, by reacting (3R,5S,6S)-6-amino-7-cyclohexyl-5-hydroxy-3-isopropylheptanoic acid butylamide with Boc-Phe-His-OH there is obtained t-butyl [(S)-α-[[(S)-1-[[(1S,2S,4R)-4-[(butylcarbamoyl)methyl]-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]phenethyl]carbamate as an amorphous solid, MS: 725 (M+H)+.

Sources & evidence

ORD record
ord-e51bdf024b7144b184df54400f57c3d8
Source dataset
uspto-grants-1992_08
Patent number
US05140011

Reaction notes

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