HCID 12960242, compound → HCID 9975627, compound

HRID 847331Notes

Reaction equation

HRID 847331 reaction equation
[Cl:1][C:2]1[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:18]([O-])=O)=[C:9]([CH:17]=1)[O:10][CH:11]([CH3:16])[C:12](OC)=[O:13]>C(O)C.[Ni]>[Cl:1][C:2]1[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]2[NH:18][C:12](=[O:13])[CH:11]([CH3:16])[O:10][C:9]=2[CH:17]=1

Participants

4

Reactant 1

HCID 12960242HCID 12960242, compound

Product 1

HCID 9975627HCID 9975627, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

Methyl 2-[5-(2-chloro-4-trifluoromethylphenoxy)-2-nitrophenoxy]propionate (1.3 g) was dissolved in 10 ml of ethanol, raney nickel was added thereto as a catalyst, and a hydrogenation was then conducted. After the completion of the reaction, the reaction mixture was filtered and concentrated in vacuo, and the residue was purified by silica gel column chromatography (developing solvent: n-hexane/ethyl acetate=1/1) to prepare the title compound (0.9 g) as a colorless crystal (yield: 88%).

Workup

  1. customAfter the completion of the reaction
  2. filtrationthe reaction mixture was filtered
  3. concentrationconcentrated in vacuo
  4. customthe residue was purified by silica gel column chromatography (developing solvent: n-hexane/ethyl acetate=1/1)

Sources & evidence

ORD record
ord-6454315fd7b342c6be13988925ca3ac4
Source dataset
uspto-grants-1992_08
Patent number
US05141551

Reaction notes

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