HCID 19880767, compound → HCID 57231206, compound

Participants

Reaction Steps

Reduced iron (1.3 g) was suspended in acetic acid (6 ml), a solution of 2-[5-(2-chloro-6-fluoro-4-trifluoromethylphenoxy)-2-nitrophenylthio]propionic acid (1.5 g) in acetic acid (2 ml) was added to the suspension, and the mixture was vigorously stirred for 20 hr. After the completion of the reaction, the reaction mixture was filtered and concentrated in vacuo, and the residue was extracted with ethyl acetate (50 ml×2), washed with water and a saturated saline solution and dried over anhydrous magnesium sulfate. The solvent was distilled off in vacuo, and the residue was purified by silica gel column chromatography (developing solvent: n-hexane/ethyl acetate=3/1) to prepare the title compound (0.9 g) as a colorless crystal (yield: 69%).

Provenance & Evidence