反应详情

A mixture of Compound 3e (239 mg, 1 mmol), 1-bromo-2-(5-methyl-2-nitrophenoxy)ethane, see G. Grynkiewicz, et al. (1985), (286 mg, 1.1 mmol), K2CO3 (83 mg, 0.6 mmol) in dry N-methylpyrrolidinone (0.75 mL) was heated at 140° C. for 10 min with protection from moisture, cooled and H2O added dropwise to precipitate the product, Compound 3f. After filtration, recrystallization from EtOH gave a white solid, m.p. 113°-114° C. Yield, 383 mg (92%).

1. temperaturecooled
2. customto precipitate the product, Compound 3f
3. filtrationAfter filtration, recrystallization from EtOH
4. customgave a white solid, m.p. 113°-114° C
5. customYield