Potassium Iodide → HCID 13520782, compound

Participants

Reaction Steps

To a solution of 13.2 g of 4-(3-chlorophenoxy)phenol (m.p. 53°-54° C.) are added 16.6 g of finely powdered potassium carbonate, 13.6 g of ethyl 2-chloroethylcarbamate and 1 g of powdered potassium iodide. With stirring, the reaction mixture is heated to +95° C. over 15 hours and then filtered. The filtrate is taken up in ice-water and extracted three times with ether. The organic extracts are washed with water, dried over sodium sulfate and concentrated by evaporation. The crude product is purified by chromatography over silica gel with a 1:3 mixture of ether/hexane to give the pure ethyl 2-[4-(3-chlorophenoxy)phenoxy]ethylcarbamate of m.p. 45°-46° C. The 1H-NMR spectrum is in conformity with the indicated structure.

Provenance & Evidence