Ethyl chloroformate → HCID 13520782, compound

Participants

Reaction Steps

With stirring, a solution of 13 g of ethyl chloroformate in 20 ml of toluene is added dropwise to a solution of 24.8 g of 2-[4-(3-chlorophenoxy)phenoxy]ethylamine and 16.8 g ethyl diisopropylamine in 150 ml of toluene, and the mixture is thereafter stirred for 15 hours at this temperature. After cooling to room temperature, the reaction mixture is washed in succession with water, 1N hydrochloric acid and, finally, with a solution of sodium chloride and dried over sodium sulfate. The solvent is removed by vacuum distillation and the crude product is further purified by chromatography over silica gel with a 1:3 mixture of diethyl ether/hexane, affording the pure ethyl 2-[4-(3-chlorophenoxy)phenoxy]ethylcarbamate of m.p. 45°-46° C. The product so obtained is identical with that obtained in Example 1A.

Provenance & Evidence