1,3-Dimethyl-2-imidazolidinone → DL-5 Chloro-6-ethyl-4-{alpha-ethyl-4-(4-cyano-2,3,5,6-tetrafluorophenoxy) benzylamino}pyrimidine

Participants

Reaction Steps

A mixture of 0.76 g of dl-5-chloro-6-ethyl-4-(αethyl-4-hydroxybenzylamino)pyrimidine, 0.5 g of pentafluorobenzonitrile, 0.4 g of anhydrous potassium carbonate and 20 ml of 1,3-dimethyl-2-imidazolidinone (DMI) was heated under stirring at 70 .C for 8 hours. After completion of the reaction, the reaction mixture was poured into water, and extracted with toluene. The extract was washed with water, dried over anhydrous sodium sulfate and then toluene was evaporated under reduced pressure. The oily product obtained was isolated by column chromatography (Wako gel C-200, eluted with toluene:ethyl acetate=10:1) to give 0.8 g of the desired product as a colorless oily product.

Provenance & Evidence