Water → HCID 15713258, compound

HRID 847378Notes

Reaction equation

HRID 847378 reaction equation
[OH-].[Na+].[F:3][CH:4]([F:22])[C:5]1([C:17]([O:19]CC)=[O:18])[CH2:10][C:9](=[CH2:11])[CH2:8][CH:7]([C:12]([O-:14])=[O:13])[N:6]1[CH:15]=[O:16].O>C(O)C>[F:22][CH:4]([F:3])[C:5]1([C:17]([OH:19])=[O:18])[CH2:10][C:9](=[CH2:11])[CH2:8][CH:7]([C:12]([OH:14])=[O:13])[N:6]1[CH:15]=[O:16]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 86745383HCID 86745383, compound

Product 1

HCID 15713258HCID 15713258, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.68 ml of 1N sodium hydroxide were added to a solution of 54 mg of the product of Step A in 4 ml of ethanol. The mixture was stirred at ambient temperature for 60 hours. 4 ml of water were added and the pH was neutralized to about 6 with Amberlyst 15 resin. After filtering and evaporating to dryness the residue was taken up in 8 ml of water and lyophilized to obtain 47 mg of the desired product in the form of its sodium salt.

Workup

  1. filtrationAfter filtering
  2. customevaporating to dryness the residue

Sources & evidence

ORD record
ord-db487df81c3d4658a45664efb4dd30f1
Source dataset
uspto-grants-1992_08
Patent number
US05141952

Reaction notes

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