3-[2,4-Bis(2-methylbutan-2-yl)phenoxy]propan-1-amine → HCID 131717501, compound

HRID 847429Notes

Reaction equation

HRID 847429 reaction equation
[OH:1][CH:2]1[CH:6]2[CH2:7][CH2:8][CH:3]1[C:4]1[C:12]([C:13](OC3C=CC=CC=3)=[O:14])=[CH:11][C:10]([OH:22])=[CH:9][C:5]=12.[C:23]([C:28]1[CH:38]=[C:37]([C:39]([CH2:42][CH3:43])([CH3:41])[CH3:40])[CH:36]=[CH:35][C:29]=1[O:30][CH2:31][CH2:32][CH2:33][NH2:34])([CH2:26][CH3:27])([CH3:25])[CH3:24]>>[OH:1][CH:2]1[CH:6]2[CH2:7][CH2:8][CH:3]1[C:4]1[C:12]([C:13](=[O:14])[NH:34][CH2:33][CH2:32][CH2:31][O:30][C:29]3[CH:35]=[CH:36][C:37]([C:39]([CH2:42][CH3:43])([CH3:41])[CH3:40])=[CH:38][C:28]=3[C:23]([CH2:26][CH3:27])([CH3:24])[CH3:25])=[CH:11][C:10]([OH:22])=[CH:9][C:5]=12

Participants

3

Reactant 2

HCID 137420883-[2,4-Bis(2-methylbutan-2-yl)phenoxy]propan-1-amineHCID 131717502HCID 131717502, compound

Product 1

HCID 131717501HCID 131717501, compound

Procedure

The phenyl ester (14.8 g) synthesized in (2) above was mixed with 3-(2,4-di-t-pentylphenoxy)propylamine (14.6 g), and the mixture was reacted at 140° C. under a reduced pressure of 20 mmHg for 4 hours. After cooling, the reaction product was crystallized from n-hexane to obtain 3,6-dihydroxy-4-[3-(2,4-di-t-pentylphenoxy)propylcarbamoyl]benzonorbornene. (Yield: 15.1 g (61.2 %), m.p.: 142° C.)

Workup

  1. customthe mixture was reacted at 140° C. under a reduced pressure of 20 mmHg for 4 hours
  2. temperatureAfter cooling
  3. customthe reaction product was crystallized from n-hexane

Sources & evidence

ORD record
ord-037422849bb14eb0bffbce1c75143033
Source dataset
uspto-grants-1992_08
Patent number
US05142029

Reaction notes

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