HCID 11757602, compound → HCID 10381413, compound

HRID 847522Notes

Reaction equation

HRID 847522 reaction equation
[CH2:1]([C:3]1([CH2:18][C:19]2[N:20]=[CH:21][N:22](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[C:23]=2[CH3:24])[C:16](=[O:17])[N:7]2[C:8]3[C:13]([C:14]([CH3:15])=[C:6]2[CH2:5][CH2:4]1)=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH3:2]>C(O)(=O)C.O>[CH2:1]([C:3]1([CH2:18][C:19]2[N:20]=[CH:21][NH:22][C:23]=2[CH3:24])[C:16](=[O:17])[N:7]2[C:8]3[C:13]([C:14]([CH3:15])=[C:6]2[CH2:5][CH2:4]1)=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH3:2]

Participants

4

Reactant 1

HCID 11757602HCID 11757602, compound

Product 1

HCID 10381413HCID 10381413, compoundYield 78%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

A solution of 7-ethyl-8,9-dihydro-10-methyl-7-[(5 -methyl-1-trityl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]-indol-6(7H)-one (0.45 g) in acetic acid (10 ml) and water (2.5 ml) was stirred at 60° C. for 2 hours. After evaporation of the solvent, the residue was diluted with ether (10 ml) and an aqueous solution of sodium hydrogencarbonate (10 ml). The resultant mixture was stirred for 30 minutes at ambient temperature. The insoluble material was collected, washed with water and ether, and dried to give crystalline 7-ethyl-8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]-pyrido[1,2-a]indol-6(7H)-one (0.20 g).

Workup

  1. customAfter evaporation of the solvent
  2. additionthe residue was diluted with ether (10 ml)
  3. customThe insoluble material was collected
  4. washwashed with water and ether
  5. customdried

Sources & evidence

ORD record
ord-ae0db229d7d44c13a1192f4f1be6c371
Source dataset
uspto-grants-1992_08
Patent number
US05141945

Reaction notes

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