反应详情

温度

40 °C

To 15 ml of 2% aqueous solution of sodium hydroxide was added 1.77 g of methyl [3,4-bis(4-methoxyphenyl)isoxazol-5-yl]acetate obtained in Reference Example 1 and the mixture was stirred at 40° C. over night. After completion of the reaction, the reaction mixture was washed with ether twice, and thereto was added 5 ml of 10% HCl while cooling with ice. The mixture was extracted with ethyl acetate, and the organic layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. The organic layer was concentrated at a reduced pressure, giving the above-identified compound as white solid.

1. customobtained in Reference Example 1
2. customAfter completion of the reaction
3. washthe reaction mixture was washed with ether twice
4. additionwas added 5 ml of 10% HCl
5. temperaturewhile cooling with ice
6. extractionThe mixture was extracted with ethyl acetate
7. washthe organic layer was washed with a saturated aqueous solution of sodium chloride
8. dry with materialdried over anhydrous magnesium sulfate
9. concentrationThe organic layer was concentrated at a reduced pressure