4-Nitrobenzoyl chloride → HCID 11002275, compound

HRID 847535Notes

Reaction equation

HRID 847535 reaction equation
[N+](C1C=CC(C(O[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=3[F:24])=[CH:13][CH:12]=2)=O)=CC=1)([O-])=O.FC1C=C(F)C=CC=1C1C=CC=CC=1.[N+:41]([C:44]1[CH:52]=[CH:51][C:47]([C:48](Cl)=[O:49])=[CH:46][CH:45]=1)([O-:43])=[O:42]>>[F:24][C:18]1[CH:19]=[C:20]([F:23])[CH:21]=[CH:22][C:17]=1[C:14]1[CH:13]=[CH:12][C:11]([C:48]([C:47]2[CH:46]=[CH:45][C:44]([N+:41]([O-:43])=[O:42])=[CH:52][CH:51]=2)=[O:49])=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 85024-Nitrobenzoyl chlorideHCID 1699742,4-Difluoro-1,1'-biphenylHCID 109918704-(2,4-Difluorophenyl)-phenyl 4-nitro-benzoate

Product 1

HCID 11002275HCID 11002275, compound

Procedure

A process for the preparation of 4-(2,4-difluorophenyl)-phenyl 4-nitro-benzoate comprising the Friedel-Crafts acylation of 2,4-difluorobiphenyl with 4-nitro-benzoyl chloride in order to obtain 4-(2,4-difluorophenyl)-4'-nitro-benzophenone and the Baeyer-Villiger oxidation of this latter.

Sources & evidence

ORD record
ord-d612508b04c741e6a69042f0b1ad4908
Source dataset
uspto-grants-1992_08
Patent number
US05142093

Reaction notes

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