HRID847609

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74758

6-(((Phenylmethoxy)carbonyl)amino)hexanoic acid

C14H19NO4

结构：CC(C)(C)OC(=O)NC(Cc1ccccc1)C(O)C(N)Cc1ccccc1

HCID14704377

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NC(Cc1ccccc1)C(O)C(Cc1ccccc1)NC(=O)CCCCCNC(=O)OCc1ccccc1

HCID22910256

未命名化合物

PROCEDURE

实验过程

N-(6-(Benzyloxycarbonylamino)hexanoic acid was coupled to the resultant compound of Example 11 using the mixed anhydride procedure of Example 54A to give the desired compound after silica gel chromatography using 75% ethyl acetate in chloroform.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5d76facf4c6341e5a2fb18df2a3e0003
来源数据集: uspto-grants-1992_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05142056
来源说明: uspto-grants-1992_08

反应 SMILES

[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=O)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:20][CH:21]([CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[CH:22]([OH:39])[CH:23]([NH:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[C:35]([O:34][C:32]([NH:31][CH:23]([CH:22]([OH:39])[CH:21]([NH:20][C:17](=[O:19])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][NH:11][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:10])[CH2:40][C:41]1[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=1)[CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:33])([CH3:38])([CH3:36])[CH3:37]