HRID847614

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID160435

Methanediimine

CH2N2

结构：Cc1ccc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)cc1

HCID2249310

未命名化合物

结构：CC(C)(C)OC(=O)NC(Cc1ccccc1)C(O)C(N)Cc1ccccc1

HCID14704377

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)N[C@H](C(=O)NC(Cc2ccccc2)C(O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)C(C)C)cc1

HCID22845645

未命名化合物

PROCEDURE

实验过程

According to the carbodiimide coupling procedure of Example 55, N-(p-toluenesulfonyl)valine was coupled to the resultant compound of Example 11 to give the desired compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-38d5dd5f7af740bd877217f01e327ce6
来源数据集: uspto-grants-1992_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05142056
来源说明: uspto-grants-1992_08

反应 SMILES

N=C=N.[C:4]1([CH3:21])[CH:9]=[CH:8][C:7]([S:10]([NH:13][C@H:14]([C:18]([OH:20])=O)[CH:15]([CH3:17])[CH3:16])(=[O:12])=[O:11])=[CH:6][CH:5]=1.[NH2:22][CH:23]([CH2:42][C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)[CH:24]([OH:41])[CH:25]([NH:33][C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[C:37]([O:36][C:34]([NH:33][CH:25]([CH:24]([OH:41])[CH:23]([NH:22][C:18](=[O:20])[C@H:14]([CH:15]([CH3:16])[CH3:17])[NH:13][S:10]([C:7]1[CH:6]=[CH:5][C:4]([CH3:21])=[CH:9][CH:8]=1)(=[O:11])=[O:12])[CH2:42][C:43]1[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=1)[CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)=[O:35])([CH3:40])([CH3:38])[CH3:39]