(+)-L-Leucine methyl ester → HCID 54294673, compound

HRID 847616Notes

Reaction equation

HRID 847616 reaction equation
[CH3:1][O:2][C:3](=[O:10])[C@H:4]([CH2:6][CH:7]([CH3:9])[CH3:8])[NH2:5]>C(#N)C=C>[CH3:1][O:2][C:3](=[O:10])[C@H:4]([CH2:6][CH:7]([CH3:9])[CH3:8])[NH:5][CH2:7][CH2:6][C:4]#[N:5]

Participants

3

Reactant 1

HCID 65105(+)-L-Leucine methyl ester

Product 1

HCID 54294673HCID 54294673, compound

Reagents, catalysts & solvents 1

HCID 7855AcrylonitrileSolvent

Procedure

A solution of leucine methyl ester (0.590 mmol) in acrylonitrile (2 ml) was heated at reflux. Evaporation provided a residue which was chromatographed on silica gel to give desired compound.

Workup

  1. temperatureat reflux
  2. customEvaporation
  3. customprovided a residue which
  4. customwas chromatographed on silica gel

Sources & evidence

ORD record
ord-39bed777d4ad4df8a45effc61a0807ab
Source dataset
uspto-grants-1992_08
Patent number
US05142056

Reaction notes

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